Have you ever craved pizza but wanted something a little different? Imagine this: a cheesy, gooey casserole that combines all the best elements of your favorite pizza with the comforting goodness of a casserole. That’s what Cheddar Bay Pizza Casserole brings to the table. It’s a dish that’s both satisfying and easy to make, perfect for busy weeknights or cozy gatherings.
What makes this dish truly special is its unique blend of flavors and textures. The rich cheddar and biscuit-like crust mimic the beloved Cheddar Bay biscuits from a popular restaurant chain, while the layers of pizza toppings create a savory experience that keeps you coming back for more. Let’s delve into this delicious recipe and discover how to make it shine in your kitchen.

Ingredients & Substitutions
Here’s what you’ll need for a delightful Cheddar Bay Pizza Casserole:
- Ground beef or Italian sausage (1 pound)
- Pizza sauce (1 jar, about 15 oz)
- Cheddar cheese (shredded, about 2 cups)
- Mozzarella cheese (shredded, about 1 cup)
- Bisquick mix (or any baking mix, about 2 cups)
- Milk (1 cup)
- Eggs (2 large)
- Italian seasoning (1 tablespoon)
- Garlic powder (1 teaspoon)
- Salt and pepper (to taste)
- Pepperoni or your favorite pizza toppings (1 cup, chopped)
- Green bell pepper or onion (optional, chopped)
Now, let’s talk substitutions. If you’re looking for a vegetarian option, swap the meat for mushrooms or a plant-based sausage. For a lighter version, use ground turkey instead of beef or sausage. You can also replace the Bisquick mix with a homemade biscuit dough if you prefer.
Choosing the right ingredients matters. Fresh herbs can elevate the flavor profile, while quality cheese ensures that gooey, melty texture we all love. Always taste your sauce; it should be well-seasoned to complement the other ingredients.

Step-by-Step Instructions
- Preheat the Oven: Start by preheating your oven to 375°F (190°C). This step is crucial for even baking.
- Cook the Meat: In a large skillet, brown the ground beef or sausage over medium heat. Make sure to break it up into small pieces. Cook until browned and no longer pink, about 5-7 minutes. Drain excess fat if necessary.
- Mix in the Sauce: Add the pizza sauce to the cooked meat. Stir well to combine. Let it simmer for a few minutes while you prepare the rest of the dish.
- Prepare the Biscuit Batter: In a mixing bowl, combine the Bisquick mix, milk, eggs, garlic powder, Italian seasoning, salt, and pepper. Stir until just combined; don’t overmix—it’s okay if there are a few lumps.
- Layer the Casserole: In a greased 9×13 inch baking dish, spread half of the biscuit batter on the bottom. This forms your base. Next, layer the meat and sauce mixture evenly over the batter.
- Add Cheese and Toppings: Sprinkle half of the cheddar cheese and all the mozzarella cheese over the meat layer. Add pepperoni or any other toppings you desire. Finish by spreading the remaining biscuit batter over the top, followed by the rest of the cheddar cheese.
- Bake: Place the casserole in the preheated oven and bake for about 30-35 minutes. The top should be golden brown, and a toothpick inserted into the center should come out clean.
- Cool and Serve: Let the casserole cool for a few minutes before slicing. Serve warm, garnished with fresh herbs if desired.
Common mistakes include overbaking, which can dry out the casserole. Keeping an eye on it during the last few minutes can help you achieve that perfect golden top.
Cooking Techniques & Science
Browning the meat is essential. This process not only enhances the flavor through the Maillard reaction but also adds texture. The caramelized bits can make a big difference in taste.
Mixing the biscuit batter should be done gently. Overmixing can lead to a dense texture instead of the light, fluffy one we want. The eggs and milk help create that rise you’ll love in each bite.
Baking at the right temperature is crucial. An oven that’s too hot can cook the top too quickly, leaving the inside undercooked. Using an oven thermometer can ensure your oven is accurate.
Serving & Pairing Suggestions
Presentation is key! Serve your Cheddar Bay Pizza Casserole in a large dish, garnished with fresh parsley or basil for that pop of color. A drizzle of olive oil can enhance the visual appeal too.
For sides, a simple green salad dressed with vinaigrette can balance the richness of the casserole. Garlic bread or cheesy breadsticks make for excellent accompaniments as well.
When it comes to drinks, a light lager or a crisp white wine like Sauvignon Blanc can complement the flavors nicely. For a non-alcoholic option, a sparkling water with lemon can refresh the palate.
Conclusion
In conclusion, Cheddar Bay Pizza Casserole is a comforting dish that combines the best of two beloved favorites: pizza and biscuits. Its layers of flavor, combined with a cheesy, gooey texture, make it a hit for any occasion.
Remember to have fun with the recipe. Feel free to customize it with your favorite toppings or spices. This dish is versatile and can adapt to your taste preferences.
FAQs
1. Can I make this casserole ahead of time?
Yes! You can assemble it a day in advance and keep it in the fridge. Just bake it when you’re ready to eat.
2. Is it freezable?
Absolutely! You can freeze it before baking. Just wrap it tightly and bake straight from the freezer, adding extra time.
3. What if I don’t have Bisquick?
You can make a homemade biscuit mix using flour, baking powder, salt, and butter. Just combine 2 cups of flour with 1 tablespoon of baking powder and a pinch of salt, then cut in 1/4 cup of butter until crumbly.
4. Can I use different cheeses?
Definitely! Feel free to mix in your favorite cheeses like Monterey Jack or pepper jack for a spicy kick.
5. How can I make it spicier?
Add sliced jalapeños, crushed red pepper flakes, or spicy sausage to amp up the heat.
So there you have it—Cheddar Bay Pizza Casserole, ready to delight your taste buds! Dive in and enjoy this flavor-packed dish that’s sure to become a family favorite.

Catherine Frank is the creative force behind FoodieGrandie.com, a cozy corner of the internet where she shares her love for home-cooked meals. From hearty dinners to sweet desserts, her recipes bring warmth and flavor to every table. Passionate about simple, delicious food, Catherine turns everyday meals into memorable moments.